This dataset includes summary demographics, economic and housing demographics, and health indicators for 72 small and medium-size cities across the country. As part of a project to learn about how the built environment impacts health and equity in small and medium-size cities, the research team interviewed stakeholders from 19 of the cities included in the data set (please see Appendices A and B of the accompanying paper for a list of these cities and the methodology for our data collection and analysis). The remaining 53 cities were selected as “peer” cities that shared one for more of the following characteristics with many of the 19 cities: similar city type (suburban, central city, etc.), range of population (small or medium-sized), and location within the same metropolitan region or the same state/part of the country. Several were selected because they had launched promising built environment interventions found in our online search of journal articles, policy reports, and case studies. The health-related data were collected from City Health Dashboard and the 500 Cities: Local Data for Better Health dataset, and the demographic data were compiled from the American Community Survey’s 2014–18 five-year estimates published by the US Census Bureau. All collected data are for the most recent year available as of May 22, 2020.